We’re going to be building on the Moon this decade — and next will be Mars, says space architect Melodie Yashar. In a visionary talk, she introduces her work designing off-world shelters with autonomous robots and 3D printers and explores how it might help uncover radical solutions to some of the problems troubling humans on Earth today.

Does the key to stopping cancer lie in the heart? Cardiologist Nicholas Leeper digs into emerging scientific research on the link between the world’s two leading causes of death, heart disease and cancer, sharing how their biological origins may be connected — and treatable with the same therapeutics. A call to challenge dogma and break down traditional silos in science, with the hope of saving lives.

“Be spreaders of facts and truths,” says scientist and immunologist Dr. Anthony Fauci. Having advised seven US presidents on various disease outbreaks including COVID-19, he shares insights on the present and future of pandemics, backed up by decades of experience in public health. Hear him dive into the latest on protecting yourself from the virus, his unwavering faith in science, what he plans to do after retiring (or “rewiring”) — and soak up some hard-won wisdom for the next generation. (This conversation, hosted by TED science curator David Biello, was part of an exclusive TED Membership event on September 20, 2022. Visit ted.com/membership to become a TED Member.)

Low-status neighborhoods in the US are often stuck between stagnating assistance from the government and gentrification at the hands of real estate developers. The result is that the brightest minds are convinced that “success” means leaving town. Urban revitalizer Majora Carter has a solution: What if we treated these communities like struggling companies? She presents a restorative economic approach to capitalism, which seeks to retain talent, build resilient communities and prove that you don’t have to move out of your neighborhood to live in a better one.

Philanthropy disruptor Sara Lomelin thinks communities can build power through collective giving and the model of “giving circles”: groups of people with shared values who come together to make change, strengthen their social fabric and help diverse solutions get funded. Learn the four steps to start a thriving giving circle in your community — and see how thousands of people worldwide are already part of this movement to usher in a new era of philanthropy that is democratic and joyful.